Suzuki - Drugs and Poisons in Humans - Handbook of Practical Analysis (Springer, 2005).pdf - eBooks - Tkanczak

Drugs and Poisons in Humans

A Handbook of Practical Analysis

Osamu Suzuki and Kanako Watanabe

Drugs and Poisons

in Humans

A Handbook of Practical Analysis

With 236 Figures and 90 Tables

123

Prof. Osamu Suzuki

Assoc. Prof. Kanako Watanabe

Department of Legal Medicine

Hamamatsu University School of Medicine

Hamamatsu City 431-3192

Japan

This is a translation of “Yaku-Doku Butsu Bunseki Jissen Handobukku” originally

published in Japanese in 2002 by Jiho, Inc. 2-6-3, Hitotsubashi, Chiyoda-ku,

Tokyo 101-8421 Japan

ISBN 3-540-22277-4 Springer-Verlag Berlin Heidelberg New York

Library of Congress Control Number: 2005921910

This work is subject to copyright. All rights are reserved, whether the whole or part of the

material is concerned, speciﬁ cally the rights of translation, reprinting, reuse of illustrations,

recitation, broadcasting, reproduction on microﬁ lm or in any other way, and storage in

data banks. Duplication of this publication or parts thereof is permitted only under the

provisions of the German Copyright Law of September 9, 1965, in its current version, and

permission for use must always be obtained from Springer. Violations are liable to

prosecution under the German Copyright Law.

Springer is a part of Springer Science+Business Media

springeronline.com

Printed in the European Union

The use of registered names, trademarks, etc. in this publication does not imply, even in the

absence of a speciﬁ c statement, that such names are exempt from the relevant protective

laws and regulations and therefore free for general use.

Product liability: The publishers cannot guarantee the accuracy of any information about

the application of operative techniques and medications contained in this book. In every

individual case the user must check such information by consulting the relevant

literature.

Editor: Thomas Mager, Heidelberg

Development Editor: Andrew Spencer, Heidelberg

Production Editor: Frank Krabbes, Heidelberg

Typesetting: Fotosatz-Service Köhler GmbH, Würzburg

Cover design: Martina Winkler, Heidelberg

SPIN: 10959534

14/2109 fk – 5 4 3 2 1 0 – Printed on acid-free paper

Foreword

It was with great pleasure that I accepted the invitation to write the foreword for Drugs

and Poisons in Humans. A Handbook of Practical Analysis . Dr. Osamu Suzuki and Dr. Mikio

Yashiki, two outstanding Japanese scientists, rst published the Handbook in Japanese in 2002.

Specialists throughout Japan contributed analytical methods for a wide variety of therapeutic

and illicit drugs, pesticides, and natural toxins and alkaloids. In fact, rarely has such a wide

spectrum of analytes and metabolites been addressed within a single reference manual.

At the beginning of the book, general topics are addressed, including instructions on han-

dling biological materials, measurement of drugs in alternative specimens, and guidance on

resolving analytical problems that may occur. ere are discussions of extraction modalities

and detection methodologies and how to select these appropriately based on the physiochemi-

cal characteristics of the drug. Analysis of speci c classes of drugs and relevant metabolites are

covered in subsequent chapters. Clinical, analytical and forensic toxicology and clinical chem-

istry laboratories will nd the volume informative and useful. Toxicologists are o en faced

with developing methods for new drugs and metabolites with little information available in the

literature. is book provides a great starting point for method development providing proce-

dures that have been utilized in real life situations. In addition, toxicologists developing new

methodologies may use this volume as a guide to selecting the most appropriate instrumenta-

tion to handle the breadth of their analytical workload.

One of the most valuable aspects of the Handbook is the inclusion of speci c case studies.

Useful also are the discussions on suggested analyte concentration ranges and troubleshooting

tips. e 2002 version of the Handbook in Japanese was judged to be highly valuable and led to

the production of an English version. is Handbook also has been updated to include addi-

tional methods and procedures for this edition.

Despite the value of these methodologies, it is essential for laboratorians to validate fully a

method within their own laboratory. Di erences in instrumentation, sample size, extraction pro-

cedures (such as di erent solid-phase extraction columns) and experience level of personnel may

vary markedly between laboratories. erefore, these methods provide help and guidance in initi-

ating a new analysis, but do not take the place of independently determining limits of detection,

quanti cation and linearity, and the selectivity and precision of the assay in their own hands. Inter-

nal standardization is always the preferred approach, although use of external standard addition

may be necessary with di cult matrices, such as decomposed postmortem specimens. Quality

assurance and quality control procedures are essential components of accurate and reliable me-

thods and should be included in the analysis of each batch of specimens. Quality control samples

should span the linear range of the assay. e issue of method validation cannot be emphasized too

strongly and is necessary for the accurate application of these diverse analytical methods.

Suzuki - Drugs and Poisons in Humans - Handbook of Practical Analysis (Springer, 2005).pdf

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika: