Modern Pharmacology With Clinical Applications.pdf

PREFACE

Clinical Applications continues our commitment

to enlisting experts in pharmacology to provide

a textbook that is up-to-date and comprehensive. De-

signed to be used during a single semester, the book fo-

cuses on the clinical application of drugs within a con-

text of the major principles of pharmacology. It is meant

to serve students in medicine, osteopathy, dentistry,

pharmacy, and advanced nursing, as well as undergrad-

uate students.

clinical scenarios and require them to apply their

knowledge to solve the problem.

Reﬁned Focus: In this edition, we chose to focus

more on drug classes rather than on individual drugs,

eliminate unnecessary detail such as chemical struc-

tures, and maintain emphasis on structure–activity rela-

tionships in drug action and development.

Updated Information: This edition also includes

new information from the clinic and the laboratory.

Emerging information has been added within chapters

and when appropriate (as in the case of herbal drugs

and erectile dysfunction), through the addition of new

chapters.

With these revisions, we hope we have provided a

book that is readable, up-to-date, comprehensive but

not exhaustive, and accurate—a text that supplies both

students and faculty with a clear introduction to mod-

ern pharmacotherapeutics.

SUMMARY OF FEATURES

This edition includes a number of new or updated fea-

tures that further enhance the appeal of the text.

Study Questions: Each chapter includes ﬁve to

seven examination questions (following the United

States Medical Licensing Examination guidelines) with

detailed answers to help students test their knowledge

of the covered material.

Case Studies: Appearing at the end of each chapter,

case studies present students with real-life examples of

Charles R. Craig

Robert E. Stitzel

T he sixth edition of Modern Pharmacology With

TABLE OF CONTENTS

I. GENERAL PRINCIPLES OF PHARMACOLOGY

19. Calcium Channel Blockers

218

1. Progress in Therapeutics 03

Robert E. Stitzel and Joseph J. McPhillips

2. Mechanisms of Drug Action

Vijay C. Swamy and David J. Triggle

20. Antihypertensive Drugs

225

David P. Westfall

21. Diuretic Drugs 239

Peter A. Friedman and William O. Berndt

22. Anticoagulant, Antiplatelet, and Fibrinolytic

(Thrombolytic) Drugs

William W. Fleming

3. Drug Absorption and Distribution

Timothy S. Tracy

4. Metabolism and Excretion of Drugs

256

Jeffrey S. Fedan

23. Hypocholesterolemic Drugs and Coronary Heart

Disease 268

Richard J. Cenedella

Timothy S. Tracy

5. Pharmacokinetics

Timothy S. Tracy

6. Drug Metabolism and Disposition in Pediatric and

Gerontological Stages of Life

IV. DRUGS AFFECTING THE CENTRAL NERVOUS

SYSTEM

Jeane McCarthy

7. Principles of Toxicology

Mary E. Davis and Mark J. Reasor

8. Contemporary Bioethical Issues in Pharmacology and

Pharmaceutical Research

24. Introduction to Central Nervous System

Pharmacology

281

Charles R. Craig

25. General Anesthesia: Intravenous and Inhalational

Agents 291

David J. Smith and Michael B. Howie

26. Opioid and Nonopioid Analgesics

Janet Fleetwood

II. DRUGS AFFECTING THE AUTONOMIC NERVOUS

SYSTEM

310

9. General Organization and Functions of the Nervous

System 83

William W. Fleming

10. Adrenomimetic Drugs 96

Tony J.-F. Lee and Robert E. Stitzel

11. Adrenoceptor Antagonists

Sandra P. Welch and Billy R. Martin

27. Local Anesthetics

336

J. David Haddox

28. Agents Affecting Neuromuscular

Transmission

338

109

Michael D. Miyamoto

29. Central Nervous System Stimulants

348

David P. Westfall

12. Directly and Indirectly Acting

Cholinomimetics

121

David A. Taylor

30. Sedative–Hypnotic and Anxiolytic Drugs

355

John W. Dailey

31. Drugs Used in Neurodegenerative Disorders

William F. Wonderlin

13. Muscarinic Blocking Drugs

134

364

Patricia K. Sonsalla

32. Antiepileptic Drugs

William F. Wonderlin

14. Ganglionic Blocking Drugs and Nicotine

141

374

Charles R. Craig

33. Drugs Used in Mood Disorders

Thomas C. Westfall

385

III. Drugs Affecting the Cardiovascular System

Herbert E. Ward and Albert J. Azzaro

34. Antipsychotic Drugs

397

15. Pharmacologic Management of Chronic Heart

Failure 151

Mitchell S. Finkel and Humayun Mirza

16. Antiarrhythmic Drugs 160

Peter S. Fischbach and Benedict R. Lucchesi

17. Antianginal Drugs

Stephen M. Lasley

35. Contemporary Drug Abuse

406

Billy R. Martin and William L. Dewey

196

V. THERAPEUTIC ASPECTS OF INFLAMMATORY

AND SELECTED OTHER CLINICAL DISORDERS

Garrett J. Gross

18. The Renin–Angiotensin–Aldosterone System and Other

Vasoactive Substances

36. Antiinﬂammatory and Antirheumatic Drugs

423

206

Karen A. Woodfork and Knox Van Dyke

37. Drugs Used in Gout

441

Lisa A. Cassis

Knox Van Dyke

xii

TABLE OF CONTENTS

38. Histamine and Histamine Antagonists

449

55. The Rational Basis for Cancer

Chemotherapy

Knox Van Dyke and Karen A. Woodfork

39. Drugs Used in Asthma 458

Theodore J. Torphy and Douglas W. P. Hay

40. Drugs Used in Gastrointestinal Disorders

630

Branimir I. Sikic

56. Antineoplastic Agents

638

470

Branimir I. Sikic

57. Immunomodulating Drugs

Lisa M. Gangarosa and Donald G. Seibert

41. Drugs Used in Dermatological Disorders 484

Eric L. Carter, Mary-Margaret Chren, and David R. Bickers

42. Drugs for the Control of Supragingival

Plaque 499

Angelo Mariotti and Arthur F. Hefti

657

Leonard J. Sauers

58. Gene Therapy 666

John S. Lazo and Jennifer Rubin Grandis

VII. DRUGS AFFECTING THE ENDOCRINE SYSTEM

VI. CHEMOTHERAPY

59. Hypothalamic and Pituitary Gland

Hormones 677

Priscilla S. Dannies

60. Adrenocortical Hormones and Drugs Affecting the

Adrenal Cortex

43. Introduction to Chemotherapy

509

Steven M. Belknap

44. Synthetic Organic Antimicrobials: Sulfonamides,

Trimethoprim, Nitrofurans, Quinolones,

Methenamine 515

Marcia A. Miller-Hjelle, Vijaya Somaraju, and J. Thomas Hjelle

45. -Lactam Antibiotics

686

Ronald P. Rubin

61. Estrogens, Progestins, and SERMs

704

526

Jeannine S. Strobl

62. Uterine Stimulants and Relaxants

716

James F. Graumlich

46. Aminoglycoside Antibiotics

538

Leo R. Brancazio and Robert E. Stitzel

63. Androgens, Antiandrogens, and Anabolic

Steroids 724

Frank L. Schwartz and Roman J. Miller

64. Drugs Used in the Treatment of Erectile

Dysfunction 735

John A. Thomas and Michael J. Thomas

65. Thyroid and Antithyroid Drugs

Steven Belknap

47. Tetracyclines, Chloramphenicol, Macrolides, and

Lincosamides

544

Richard P. O’Connor

48. Bacitracin, Glycopeptide Antibiotics, and the

Polymyxins

552

742

Mir Abid Husain

49. Drugs Used in Tuberculosis and Leprosy

557

John Connors

66. Parathyroid Hormone, Calcitonin, Vitamin D, and Other

Compounds Related to Mineral Metabolism

Vijaya Somaraju

50. Antiviral Drugs 567

Knox Van Dyke and Karen Woodfork

51. Therapy of Human Immunodeﬁciency Virus

754

Frank L. Schwartz

67. Insulin and Oral Drugs for Diabetes Mellitus

763

584

Michael J. Thomas and John A. Thomas

68. Vitamins

Knox Van Dyke and Karen Woodfork

52. Antifungal Drugs

777

596

Suzanne Barone

69. Herbal Medicine

David C. Slagle

53. Antiprotozoal Drugs

785

606

Gregory Juckett

Index

Leonard William Scheibel

54. Anthelmintic Drugs 621

Mir Abid Husain and Leonard William Scheibel

GENERAL PRINCIPLES

OF PHARMACOLOGY

SECTION

1. Progress in Therapeutics 3

Robert E. Stitzel and Joseph J. McPhillips

2. Mechanisms of Drug Action

6. Drug Metabolism and Disposition in

Pediatric and Gerontological Stages

of Life ••

Jeane McCarthy

7. Principles of Toxicology ••

Mary E. Davis and Mark J. Reasor

8. Contemporary Bioethical Issues in

Pharmacology & Pharmaceutical

Research ••

Janet Fleetwood

William W. Fleming

3. Drug Absorption and Distribution

Timothy S. Tracy

4. Metabolism and Excretion of Drugs

••

Timothy S. Tracy

5. Pharmacokinetics

••

Timothy S. Tracy

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika: