Inorganic Biochemistry of Iron Metabolism From Molecular Mechanisms to Clinical Consequences 2d ed - Robert Crichton.pdf

(7506 KB) Pobierz
5067304 UNPDF
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to
Clinical Consequences. 2e
Robert Crichton
2001 John Wiley & Sons Ltd
ISBNs: 0-471-49223-X (Hardback); 0-470-84579-1 (Electronic)
Inorganic Biochemistry
of Iron Metabolism
Copyright
Inorganic Biochemistry
of Iron Metabolism
From Molecular Mechanisms
to Clinical Consequences
Second Edition
Robert Crichton
Universit´eCatholiquedeLouvain,Belgium
With the collaboration of
Johan R. Boelaert, Volkmar Braun, Klaus Hantke, Jo J. M. Marx,
Manuela Santos and Roberta Ward
JOHN WILEY & SONS, LTD
Chichester • New York • Weinheim • Brisbane • Singapore • Toronto
Copyright
2001 John Wiley & Sons, Ltd
Baffins Lane, Chichester,
West Sussex PO19 1UD, England
National 01243 779777
International (
+
44) 1243 779777
e-mail (for orders and customer service enquiries): cs-books@wiley.co.uk
Visit our Home Page on http://www.wiley.co.uk
or
http://www.wiley.com
All Rights Reserved. No part of this publication may be reproduced, stored
in a retrieval system, or transmitted, in any form or by any means, electronic,
mechanical, photocopying, recording, scanning or otherwise, except under the terms
of the Copyright, Designs and Patents Act 1988 or under the terms of a licence issued
by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 0LP, UK
without the permission of the Publisher and the copyright owner, with the exception
of any material supplied specifically for the purpose of being entered and executed
on a computer system, for the exclusive use by the purchaser of the publication.
Other Wiley Editorial Offices
John Wiley & Sons, Inc., 605 Third Avenue,
New York, NY 10158-0012, USA
Wiley-VCH Verlag GmbH, Pappelallee 3,
D-69469 Weinheim, Germany
John Wiley & Sons Australia Ltd, 33 Park Road, Milton,
Queensland 4064, Australia
John Wiley & Sons (Asia) Pte Ltd, 2 Clementi Loop #02-01,
Jin Xing Distripark, Singapore 129809
John Wiley & Sons (Canada) Ltd, 22 Worcester Road,
Rexdale, Ontario, M9W 1L1, Canada
Library of Congress Cataloguing-in-Publication Data
Crichton, Robert R.
Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical
consequences / Robert Crichton ; with the collaboration of Johan Boelart ... [ et al .].--2nd ed.
p. cm.
Includes bibliographical references and index.
ISBN 0-471-49223-X (alk. paper)
1. Iron--Metabolism. 2. Iron proteins. 3. Iron--Metabolism--Disorders. I. Boelart,
Johan. II. Title.
QP535.F4 C75 2001
572 .5174--dc21
2001026202
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library.
ISBN 0-471-49223-X
Typeset in 10.5/12.5pt Palatino by Laser Words, Chennai, India
Printed and bound in Great Britain by Antony Rowe, Chippenham, Wiltshire.
This book is printed on acid-free paper responsibly manufactured from sustainable
forestry in which at least two trees are planted for each one used for paper production.
Contents
Preface
xv
1 Solution Chemistry of Iron in Biological Media
1
1.1 Aqueous Solution Chemistry of Iron
1
1.2 Oxygen Free Radicals
2
1.3 Iron Hydrolysis – A Ubiquitous Phenomenon
6
1.4 Hydrolysis of Iron(III) in Acid Media – Formation
of Polynuclear Species
6
1.5 Formation of Precipitates
8
1.5.1 Ageing of Amorphous Ferrihydrite to More-crystalline Products
9
1.6 Biomineralization
11
1.6.1 Magnetite Biomineralization by Magnetotactic Bacteria
11
1.7 References
14
2 The Importance of Iron for Biological Systems
17
2.1 Introduction
17
2.2 Physical Techniques for the Study of Iron in Biological Systems
20
2.3 Haemoproteins
22
2.3.1 Oxygen Carriers
22
2.3.2 Activators of Molecular Oxygen
25
2.3.3 Electron Transport Proteins
31
5067304.001.png
vi
Contents
2.4 Iron–Sulfur Proteins
34
2.5 Other Iron-containing Proteins
37
2.5.1 Mononuclear Non-haem Iron Enzymes
40
Dioxygenases
40
Hydroxylases
41
a -Ketoacid-dependent Enzymes
42
Isopenicillin N Synthase
43
Superoxide Dismutases
43
2.5.2 Dinuclear Non-haem Iron Enzymes
44
( m -Carboxylato)diiron Proteins
45
2.6 References
48
3 Microbial Iron Uptake
49
3.1 Introduction
49
3.2 Siderophores
51
3.2.1 FhuA-mediated Ferrichrome Transport Across
the Outer Membrane–of E. coli
54
3.2.2 FhuA as an Antibiotic Transporter
58
3.2.3 Transport of Ferrichrome Across the Cytoplasmic Membrane
58
3.2.4 Variety of Fe 3 + Transport Systems in Bacteria
63
3.3 Ferrous Iron Transport Systems
63
3.4 Iron Metabolism
64
3.5 Iron Regulation in Bacteria – the Fur Protein
65
3.5.1 The Fur Regulon
66
3.5.2 Siderophore Biosynthesis and Uptake
66
3.5.3 Iron Metabolism and Oxidative Stress Response
70
3.5.4 Genes Regulated by Fur
71
3.5.5 Virulence-Associated Genes
71
3.5.6 Fur-like Proteins
71
DtxR-like Regulators
72
3.5.7 Regulation by Fe 3 + Siderophores
73
3.5.8 Regulation of Outer Membrane Transporter Synthesis
by Phase Variation
74
3.5.9 Iron-related Bacterial Virulence
75
3.6 Acknowledgements
76
3.7 References
76
5067304.002.png

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin