pathogenesis of neurodegenerative disorders.pdf

Pathogenesis of

Neurodegenerative

Disorders

Edited by

Mark P. Mattson

HUMANA PRESS

Pathogenesis of Neurodegenerative Disorders

Contemporary Neuroscience

Pathogenesis of Neurodegenerative Disorders,

edited by Mark P. Mattson , 2001

Neurobiology of Spinal Cord Injury , edited

by Robert G. Kalb and Stephen M.

Strittmatter, 2000

Cerebral Signal Transduction: From First to

Fourth Messengers, edited by Maarten E.

A. Reith, 2000

Central Nervous System Diseases: Innovative

Animal Models from Lab to Clinic, edited

by Dwaine F. Emerich, Reginald L.

Dean, III, and Paul R. Sanberg, 2000

Mitochondrial Inhibitors and Neurodegen-

erative Disorders, edited by Paul R.

Sanberg, Hitoo Nishino, and Cesario V.

Borlongan, 2000

Cerebral Ischemia: Molecular and Cellular

Pa thophysiology, edited by Wolfgang

Walz , 1999

Cell Transplantation for Neurological

Disorders, edited by Thomas B. Freeman

and Håkan Widner, 1998

Gene Therapy for Neurological Disorders

and Brain Tumors, edited by E. Antonio

Chiocca and Xandra O. Breakefield,

1998

Highly Selective Neurotoxins: Basic and

Clinical Applications, edited by Richard

M. Kostrzewa, 1998

Neuroinflammation: Mechanisms and

Management, edited by Paul L. Wood,

1998

Neuroprotective Signal Transduction, edited

by Mark P. Mattson, 1998

Clinical Pharmacology of Cerebral Ischemia,

edited by Gert J. Ter Horst and Jakob

Korf, 1997

Molecular Mechanisms of Dementia, edited

by Wilma Wasco and Rudolph E. Tanzi,

1997

Neurotransmitter Transporters: Structure,

Function, and Regulation, edited by

Maarten E. A. Reith, 1997

Motor Activity and Movement Disorders:

Research Issues and Applications,

edited by Paul R. Sanberg, Klaus-Peter

Ossenkopp, and Martin Kavaliers, 1996

Neurotherapeutics: Emerging Strategies,

edited by Linda M. Pullan and Jitendra

Patel, 1996

Neuron–Glia Interrelations During

Phylogeny: II. Plasticity

and Regeneration, edited by Antonia

Ve rnadakis and Betty I. Roots, 1995

Neuron–Glia Interrelations During

Phylogeny: I. Phylogeny

and Ontogeny of Glial Cells, edited by

Antonia Vernadakis and Betty I. Roots,

1995

The Biology of Neuropeptide Y and Related

Peptides, edited by William F. Colmers

and Claes Wahlestedt, 1993

Psychoactive Drugs: Tolerance and Sensiti-

zation, edited by A. J. Goudie and M. W.

Emmett-Oglesby, 1989

Experimental Psychopharmacology, edited

by Andrew J. Greenshaw and Colin T.

Dourish, 1987

Developmental Neurobiology of the Auto-

nomic Nervous System, edited by Phyllis

M. Gootman, 1986

The Auditory Midbrain, edited by Lindsay

Aitkin, 1985

Neurobiology of the Trace Elements, edited by

Ivor E. Dreosti and Richard M. Smith:

Vol. 1: Trace Element Neurobiology and

Deficiencies, 1983; Vol. 2: Neurotoxicology

and Neuropharmacology, 1983

Pathogenesis of

Neurodegenerative

Disorders

Edited by

Mark P. Mattson

National Institute on Aging, Baltimore, MD

Humana Press

Totowa, New Jersey

999 Riverview Drive, Suite 208

Totowa, New Jersey 07512

No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,

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This publication is printed on acid-free paper. '

ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials.

Cover illustration: The cover shows a silver-strained tissue section from the hippocampus of a patient with Alzheimer’s

disease. The flame-shaped cell bodies of degenerating neurons (neurofibrillary tangles) and their neurites associated

with amyloid deposits are stained black. The inset shows an electron micrograph of a cultured embryonic human cerebral

cortical neuron that had been exposed to conditions that disrupt cellular calcium homeostasis and trigger a form of

programmed cell death called apoptosis. Micrographs provided by M. P. Mattson.

Cover design by Patricia F. Cleary.

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Press Inc. The fee code for users of the Transactional Reporting Service is: [0-89603-838-6/01 $10.00 + $00.25].

Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1

Library of Congress Cataloging-in-Publication Data

The pathogenesis of neurodegenerative disorders / edited by Mark P. Mattson.

p. c.m.––(Contemporary neuroscience)

Includes bibliographical references and index.

ISBN 0-89603-838-6 (alk. paper)

1. Nervous system––Degeneration––Pathogenesis. I. Mattson, Mark Paul. II. Series.

RC365 .P385 2001

616.8'0407––dc21

00-063355

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