Marijuana and Medicine Assessing the Science Base 0309071550.pdf

PREFACE

Marijuana

and Medi c ine

Assessing the Science Base

Janet E. Joy, Stanley J. Watson, Jr., and

John A. Benson, Jr., Editors

Division of Neuroscience and Behavioral Health

INSTITUTE OF MEDICINE

NATIONAL ACADEMY PRESS

Washington, D.C.

NATIONAL ACADEMY PRESS • 2101 Constitution Avenue, N.W. • Washington, D.C. 20418

NOTICE: The project that is the subject of this report was approved by the Governing Board

of the National Research Council, whose members are drawn from the councils of the Na-

tional Academy of Sciences, the National Academy of Engineering, and the Institute of Medi-

cine. The principal investigators responsible for the report were chosen for their special

competences and with regard for appropriate balance.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences

to enlist distinguished members of the appropriate professions in the examination of policy

matters pertaining to the health of the public. In this, the Institute acts under both the

Academy’s 1863 congressional charter responsibility to be an adviser to the federal govern-

ment and its own initiative in identifying issues of medical care, research, and education. Dr.

Kenneth I. Shine is president of the Institute of Medicine.

This study was supported under Contract No. DC7C02 from the Executive Office of the

President, Office of National Drug Control Policy.

Library of Congress Cataloging-in-Publication Data

Marijuana and medicine : assessing the science base / Janet E. Joy,

Stanley J. Watson, Jr., and John A. Benson, Jr., editors ; Division

of Neuroscience and Behavioral Health, Institute of Medicine.

p. cm.

Includes bibliographical references and index.

ISBN 0-309-07155-0 (hardcover)

1. Marijuana—Therapeutic use. 2. Cannabinoids—Therapeutic use.

I. Joy, Janet E. (Janet Elizabeth), 1953- II. Watson, Stanley J.,

1943- III. Benson, John A. IV. Institute of Medicine (U.S.).

Division of Neuroscience and Behavioral Health.

RM666.C266 M365 1999

615

′

Additional copies of this report are available for sale from the National Academy Press,

2101 Constitution Avenue, N.W., Lock Box 285, Washington, D.C. 20055. Call (800) 624-6242

or (202) 334-3313 (in the Washington metropolitan area), or visit the NAP’s online bookstore

at www.nap.edu.

The full text of this report is available online at www.nap.edu.

For more information about the Institute of Medicine, visit the IOM home page at:

www4.nas.edu/IOM/.

Printed in the United States of America

Cover: Illustration from Marijuana Botany by Robert Connell Clarke, Ronin Publishing, 1981.

The serpent has been a symbol of long life, healing, and knowledge among almost all

cultures and religions since the beginning of recorded history. The image adopted as a logo-

type by the Institute of Medicine is based on a relief carving from ancient Greece, now held

by the Staatliche Museen in Berlin.

.32345—dc21

99-6484

PRINCIPAL INVESTIGATORS AND ADVISORY PANEL

JOHN A. BENSON, JR. ( Co-Principal Investigator ) , Dean and Professor

of Medicine, Emeritus, Oregon Health Sciences University School of

Medicine

STANLEY J. WATSON, JR. (C o-Principal Investigator ) , Co-Director and

Research Scientist, Mental Health Research Institute, University of

Michigan

STEVEN R. CHILDERS, Professor of Physiology and Pharmacology,

Center for Neuroscience, Bowman Gray School of Medicine, Wake

Forest University

J. RICHARD CROUT, President of Crout Consulting, Drug

Development and Regulation, Bethesda, Maryland

THOMAS J. CROWLEY, Professor, Department of Psychiatry, and

Executive Director, Addiction Research and Treatment Services,

University of Colorado Health Sciences Center

JUDITH FEINBERG, Professor, Department of Internal Medicine, and

Associate Director, Division of Infectious Diseases, University of

Cincinnati School of Medicine

HOWARD L. FIELDS, Professor of Neurology and Physiology,

University of California at San Francisco

DOROTHY HATSUKAMI, Professor of Psychiatry, University of

Minnesota

ERIC B. LARSON, Medical Director, University of Washington Medical

Center, and Associate Dean for Clinical Affairs, University of

Washington

BILLY R. MARTIN, Professor of Pharmacology and Toxicology, and

Director of National Institute on Drug Abuse Center on Drug

Abuse, Medical College of Virginia, Virginia Commonwealth

University

TIMOTHY L. VOLLMER, Professor of Medicine, Multiple Sclerosis

Research Center, Yale University School of Medicine

Study Staff

JANET E. JOY, Study Director

DEBORAH O. YARNELL, Research Associate

AMELIA B. MATHIS, Project Assistant

CHERYL MITCHELL, Administrative Assistant (until September 1998)

THOMAS J. WETTERHAN, Research Assistant (until September 1998)

CONSTANCE M. PECHURA, Division Director (until April 1998)

NORMAN GROSSBLATT, Manuscript Editor

iii

Consultant

MIRIAM DAVIS

Section Staff

CHARLES H. EVANS, JR., Head, Health Sciences Section

LINDA DEPUGH, Administrative Assistant

CARLOS GABRIEL, Financial Associate

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