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Industrial Pharmaceutical Biotechnology.
Heinrich Klefenz
Copyright © 2002 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29995-5 (Hardcover); 3-527-60012-4 (Electronic)
I
Heinrich Klefenz
Industrial Pharmaceutical Biotechnology
Industrial Pharmaceutical Biotechnology.
Heinrich Klefenz
Copyright © 2002 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29995-5 (Hardcover); 3-527-60012-4 (Electronic)
III
Heinrich Klefenz
Industrial Pharmaceutical
Biotechnology
IV
Industrial Pharmaceutical Biotechnology.
Heinrich Klefenz
Copyright © 2002 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29995-5 (Hardcover); 3-527-60012-4 (Electronic)
Dr. Heinrich Klefenz
Hauptstr. 35
D-76879 Bornheim
Germany
This book was carefully produced. Nevertheless, author and publisher do not warrant the informa-
tion contained therein to be free of errors. Readers are advised to keep in mind that statements, data,
illustrations, procedural details or other items may inadvertently be inaccurate.
Cover illustration: Design by ‘das trio kommunikation und marketing gmbh; Mannheim, München’
Copyright of and reprint permissions granted by
American Society for Microbiology (Tables 7.1, 7.2; ref. 502)
American Association for the Advancement of Science (Tables: 4.7, ref. 219; 5.1, ref. 224; Figures: 4.1,
ref. 154; 4.2, ref. 510; 6.1, ref. 301)
Nature Publishing Group (Fig. 1.3, ref. 432; Tables: 1.6, ref. 432; 1.7, ref. 433; 1.8, ref. 436; 1.9, ref.
437; 1.10, ref. 439).
Library of Congress Card No.: Applied for.
British Library Cataloguing-in-Publication Data:
A catalogue record for this book
is available from the British Library
Die Deutsche Bibliothek Cataloguing-in-Publication Data:
A catalogue record for this publication is available from Die Deutsche Bibliothek
ISBN 3-527-29995-5
© WILEY-VCH Verlag GmbH, Weinheim (Federal Republic of Germany), 2002
Printed on acid-free paper.
All rights reserved (including those of translation into other languages). No part of this book may be
reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated
into a machine language without written permission from the publishers. Registered names, trademarks,
etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by
law.
Composition: Manuela Treindl, Regensburg
Printing: Strauss Offsetdruck GmbH, Mörlenbach
Bookbinding: J. Schäffer GmbH & Co. KG, Grünstadt
Printed in the Federal Republic of Germany.
Industrial Pharmaceutical Biotechnology.
Heinrich Klefenz
Copyright © 2002 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29995-5 (Hardcover); 3-527-60012-4 (Electronic)
Preface
Biotechnology and its applications in medicine, pharma, and related industries represent
one of the most influential developments and pose one of the greatest challenges of the 21
st
century, both with respect to its political, societal, and ethical implications and in the search
for the fulfillment of its promises for health.
Biotechnology is stepping beyond previously insurmountable boundaries in understanding
and manipulating life, in the efforts to understand biology, to eradicate disease, to maintain
health and vigor, and to endow humans and life forms with desired properties.
This book aims to describe a fast-moving subject (or rather a whole interconnected sys-
tem of subjects) and, like in optics, some parts of the picture may be blurred and will
require further refining. It pulls together topics, which are essential for the realization of
the promises of biomedicine – the repertoire of genomics, proteomics, cytomics, bio-
informatics, and the interaction of networks – and combines with pertinent methods in
nanotechnologies, such as engineering tools to design and construct devices, artificial in-
telligence and vision processing for nano-devices, implantates, and for the envisioned swarms
of remedial nano-robots.
Crucial topics for future therapies are regenerative medicine and the cultivation of tis-
sues and organs as well as the underlying genetics and regulatory, developmental, bio-
chemical networks.
Complex traits, critical in multifactor and degenerative diseases, are being dealt with,
with a focus on senescence which forms the background against which numerous degen-
erative and acute diseases develop, the elucidation of which will facilitate the strengthening
of immune responses, the maintenance of homeostasis and biochemical networks, the pres-
ervation of the integrity of genetic and cellular structures.
Drug discovery encompasses the identification of molecular structures, the creation of
active molecules, and the development of novel comprehensive therapies like immuno-
therapy and cellular or organismal therapy with genetically engineered cells.
Biotechnology, chemistry, physics provide the tools for target identification, for the cre-
ation of new molecular structures, and for the recovery of biologically active molecules
provided by the biosphere and efficiency-honed during continuous evolutionary processes.
The huge amounts of data and information alone will not be sufficient to lead to new
molecular entities and novel therapies, since synthesizing millions of compounds will nei-
ther fill the universe of potential molecular structures nor allow the identification of those
three-dimensional structures specifically interacting with targets. The knowledge of the
biological processes and structures as the templates and targets for the identification of
active molecules is indispensable.
Biological plus chemical functional information and knowledge of interactions and net-
works will be the foundation to which the essential components of creativity and innova-
V
VI
Preface
tion (and chance) are to be added as keys for the successful application of the pertinent
technologies.
The reference list of more than 700 literature citations is meant to underpin the contents
and the conclusions of the book’s theme, and to serve as a starting point for delving deeper
into individual subjects.
Special thanks go to Dr. Hovsep Sarkissian for his support in layout, in the production of
figures and tables, in proofreading and the generation of a readable manuscript. Thanks are
also due to the staff of Wiley-VCH for their organization, continuous encouragement, and
stimulation; and to the ‘Muttersprachler’ who critically read the English manuscript pro-
vided and contributed to the professionalism of the writing.
Utmost to be thankful for is the patience, understanding, and support of my family and
our two children who have tolerated extended periods of negligence.
Undoubtedly the rapid development in biotechnology, biomedicine, and supporting tech-
nologies, will affect many topics of the book’s field and will necessitate modifying, chang-
ing, or complementing the subjects.
I have no doubt that in our efforts to fulfill the potential of pharmaceutical biotechnol-
ogy, we are on a steep uphill slope and the top of the mountain (control of health, disease,
and desired properties) is in the clouds at incalculable but reachable distance.
I welcome critical comments or suggestions about the book, proposals for areas to be
dealt with in the future, and I am ready to provide further details, information, or references
about the various topics upon request.
H. Klefenz
Bornheim, December 2001
e-mail address: sarkle@t-online.de
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