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CONTENTS
Volume 314, Issue 5805
COVER
The grass
Sorghastrum nutans
, one of
a dozen plant species that dominate
native North American prairies.
Biofuels produced from diverse mixtures
of prairie plants can provide greater
energy yields and environmental
benefits than food-based biofuels
such as corn ethanol and soybean
biodiesel. See
page 1598.
Photo: Jason Hill
DEPARTMENTS
1511
Science
Online
1512
This Week in
Science
1516
Editors’ Choice
1518
Contact
Science
1519
Random Samples
1521
Newsmakers
1614
New Products
1615
Science
Careers
EDITORIAL
1515
Show Us the Money
by Donald Kennedy
LETTERS
Deciding Who Should Get the Flu Vaccine
NEWS OF THE WEEK
Tracking Ebola’s Deadly March Among Wild Apes
1522
1539
M. Holmberg
Response
E. J. Emanuel and
A. Wertheimer
The Cost of Access to HIV Treatment
P. Galatowitsch and
N. Siegfried
Response
R. M. Grant
et al.
Responding to Amphibian Loss
J. A. Pounds
et al.
Response
J. R. Mendelson III
et al.
>> Brevia
p. 1564
Unprecedented Budget Increase Draws Faint Praise
1523
A Season of Generosity … and Jeremiads
1525
SCIENCESCOPE
1525
U.S. Study Finds Slower Breakdown of Plutonium
1526
in Stockpiled Weapons
Ancient Cataclysm Marred the Med
BOOKS
ET AL.
Science Books for Fun and Learning—
1527
1543
Mars Orbiter’s Swan Song: The Red Planet
1528
Some Recommendations from 2006
The Swarm A Novel of the Deep
Is A-Changin’
>> Research Article
p. 1573
A Shot of Oxygen to Unleash the Evolution of Animals
1546
F. Schätzing, reviewed by B. Worm
1529
>>
Science
Express Report by D. E. Canfield
et al.
POLICY FORUM
Where Is the New Science in Corporate R&D?
1547
NEWS FOCUS
Neurobiology on the Farm
J. Thursby and M. Thursby
1530
PERSPECTIVES
Microwave Cooling of an Artificial Atom
A Stone Age World Beneath the Baltic Sea
1533
A Hunter’s Paradise
Getting a Read on Rett Syndrome
1549
1536
I. Chiorescu
>> Report
p. 1589
A Ghostly Star Revealed in Silhouette
1550
P. F. L. Maxted
>> Report
p. 1578
Big Bang Points to Stellar Mix-Up
1551
P. Podsiadlowski and S. Justham
>> Report
p. 1580
Pulling Strings
1552
W. Fontana
>> Reports
pp. 1583
and
1585
Matters of Size
1554
1554
C. Kopec and R. Malinow
The Puzzle of Human Sociality
1555
R. Boyd
>> Review
p. 1560;
Research Article
p. 1569
An Ancient Carbon Mystery
1556
M. Pagani, K. Caldeira, D. Archer, J. C. Zachos
ESSAY
GE Prize-Winning Essay: The Emergence of Cells
1558
During the Origin of Life
I. A. Chen
1530
CONTENTS
continued
>>
1505
www.sciencemag.org
SCIENCE
VOL 314
8 DECEMBER 2006
CONTENTS
SCIENCE EXPRESS
www.sciencexpress.org
GEOCHEMISTRY
Late-Neoproterozoic Deep-Ocean Oxygenation and the Rise of Animal Life
D. E. Canfield, S. W. Poulton, G. M. Narbonne
A record based on iron species in minerals implies that the deep ocean only
became oxygenated after the last major Precambrian glaciation, just before
the rise of metazoans.
>> News story
p. 1529
BIOCHEMISTRY
An Inward-Facing Conformation of a Putative Metal-Chelate–Type
ABC Transporter
H. W. Pinkett, A. T. Lee, P. Lum, K. P. Locher, D. C. Rees
A pump moves molecules out of cells by coupled changes in the nucleotide-binding
domain and the membrane-spanning helices, which switch the accessibility of the
central cavity from outside to inside.
10.1126/science.1135013
10.1126/science.1133488
MOLECULAR BIOLOGY
Secondary siRNAs Result from Unprimed RNA Synthesis and Form a
Distinct Class
T. Sijen, F. A. Steiner, K. L. Thijssen, R. H. A. Plasterk
A distinct class of small antisense RNAs is synthesized by RNA-directed RNA
polymerase from siRNA templates in
Caenorhabditis elegans
.
10.1126/science.1136699
CHEMISTRY
Organic Glasses with Exceptional Thermodynamic and Kinetic Stability
S. F. Swallen
et al.
Organic molecules can form stable glasses when deposited from a vapor onto a
substrate cooled only 50 kelvin below their usual glass transition temperature.
10.1126/science.1135795
EVOLUTION
Group Competition, Reproductive Leveling, and the
REVIEW
EVOLUTION
Five Rules for the Evolution of Cooperation
1569
Evolution of Human Altruism
S. Bowles
Early human practices requiring language and sophisticated
cognition enhanced the contribution of altruism to group survival,
perhaps selecting for altruistic traits.
>> Perspective
p. 1555
PLANETARY SCIENCE
Present-Day Impact Cratering Rate and
1560
M. A. Nowak
>> Perspective
p. 1555
BREVIA
ECOLOGY
Ebola Outbreak Killed 5000 Gorillas
1564
1573
M. Bermejo
et al.
Successive waves of Ebola virus infection and hunting pressure
are threatening the great apes of West Africa with extinction.
>> News story
p. 1522
Contemporary Gully Activity on Mars
M. C. Malin
et al.
Images of Mars taken 7 years apart reveal 20 new impact craters,
close to the predicted rate, some with gullies indicating the presence
of flowing water in the past decade.
>> News story
p. 1528
RESEARCH ARTICLES
MICROBIOLOGY
Engineering Yeast Transcription Machinery for
REPORTS
ASTRONOMY
A Brown Dwarf Mass Donor in an Accreting Binary
1565
Improved Ethanol Tolerance and Production
H. Alper
et al.
Yeast genetically altered to tolerate higher ethanol and glucose
concentrations may prove useful for biofuel production.
1578
S. P. Littlefair
Accurate measurements of eclipses finally capture a white dwarf
cannibalizing an unseen brown dwarf companion star, confirming
long-standing predictions.
>> Perspective
p. 1550
1528
&
1573
CONTENTS
continued
>>
1507
www.sciencemag.org
SCIENCE
VOL 314
8 DECEMBER 2006
CONTENTS
REPORTS
CONTINUED...
ASTRONOMY
Deep Mixing of
3
He: Reconciling Big Bang and
MOLECULAR BIOLOGY
Synthesis-Mediated Release of a Small RNA
1580
1601
Stellar Nucleosynthesis
P. P. Eggleton, D. S. P. Dearborn, J. C. Lattanzio
Three-dimensional models of giant stars show that deep convection
of supposedly stable layers destroys
3
He to levels consistent with the
Big Bang predictions.
>> Perspective
p. 1551
CHEMISTRY
Operation of a DNA Robot Arm Inserted into a
Inhibitor of RNA Polymerase
K. M. Wassarman and R. M. Saecker
When bacteria are starved, a small RNA inhibits transcription
by folding to mimic a legitimate promoter target, after which
adding nucleotides can restart transcription.
MEDICINE
Dual Infection with HIV and Malaria Fuels the
1583
1603
2D DNA Crystalline Substrate
B. Ding and N. C. Seeman
A mechanical DNA device mounted within a crystalline
DNA lattice retains its functionality, providing a step toward
nanoscale computation and manufacturing.
>> Perspective
p. 1552
CHEMISTRY
Enzyme-Free Nucleic Acid Logic Circuits
Spread of Both Diseases in Sub-Saharan Africa
L. J. Abu-Raddad, P. Patnaik, J. G. Kublin
Malaria infection increases HIV blood levels and HIV patients are
more susceptible to malaria, a synergy that probably contributes to
the HIV epidemic in Africa.
MICROBIOLOGY
A Positive Feedback Loop Promotes Transcription
1607
1585
Surge That Jump-Starts
Salmonella
Virulence Circuit
D. Shin, E.-J. Lee, H. Huang, E. A. Groisman
Activation of a two-component signaling pathway required
for
Salmonella
virulence triggers a burst of transcription
that may allow rapid adaptation to new conditions.
NEUROSCIENCE
Sequential Interplay of Nicotinic and GABAergic
G. Seelig, D. Soloveichik, D. Y. Zhang, E. Winfree
Single-stranded DNAs are used to create a series of computation
gates, circuits, and devices in a modular fashion.
>> Perspective
p. 1552
PHYSICS
Microwave-Induced Cooling of a Superconducting
1589
1610
Qubit
S. O. Valenzuela
et al.
A microwave cooling technique can lower the temperature of a qubit
to 3 millikelvin, much lower than the temperature of the surrounding
bath, enhancing its stability.
>> Perspective
p. 1549
ANTHROPOLOGY
U-Pb Isotopic Age of the StW 573 Hominid from
Signaling Guides Neuronal Development
Z. Liu, R. A. Neff, D. K. Berg
Acetylcholine changes chloride transporter levels, triggering a switch
from excitatory to inhibitory signaling in the embryonic chick brain.
1592
Sterkfontein, South Africa
J. Walker, R. A. Cliff, A. G. Latham
Dating of cave deposits establishes the australopithicine “little foot,”
as 2.2 million years old, surprisingly recent and contemporaneous
with tool-using
Homo
species.
DEVELOPMENTAL BIOLOGY
A Complex Oscillating Network of Signaling Genes
1595
Underlies the Mouse Segmentation Clock
M.-L. Dequéant
et al.
The segmentation clock, which forms repeated body structures during
development, generates many oscillating RNAs that regulate common
developmental pathways.
ECOLOGY
Carbon-Negative Biofuels from Low-Input
1598
High-Diversity Grassland Biomass
D. Tilman, J. Hill, C. Lehman
Sustainable, higher-diversity grasslands with low-fertility soils can
yield more biomass and consume more CO
2
than equal acreages
planted with monocultured biofuel sources.
1551
&
1580
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for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005.
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CONTENTS
continued
>>
1509
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SCIENCE
VOL 314
8 DECEMBER 2006
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